The misc.fitness.weights FAQ Table of Contents
The dosage varies depending on the ailment being treated. What does Hans the counting horse demonstrate? It should feel like you are sitting back on a chair behind you; not going straight down. Need Help Finding a Diet? Clinical trials on humans, involving either oral doses of methyltestosterone or injections of testosterone propionate , began as early as
What is Forskolin?
High blood pressure can lead to many ailments and sometimes death. According to two trials, after 12 weeks in one study and 2 months in the other, results were favorable as both groups experienced drops in blood pressure.
Forskolin and its weight loss benefits were tested on different occasions with different results. The lipolysis capabilities of forskolin are an intriguing benefit, but as far as medical studies go, there is not enough evidence to definitively call forskolin a fat burner. One study found that although Forskolin did not result in weight loss in overweight women, it did seem to result in the participants not gaining any additional weight.
Forskolin is marketed commercially as pills, containing anywhere from mg to mg and is usually taken twice a day. According to supplement companies, taking forskolin supplement pills such as Forskolin Fuel and Forskolin Slim has to be done daily, and should continue after weight-loss as maintenance.
Science reports that while higher amounts of Forskolin do increase lipolysis, which means the release of fat from adipose fatty tissue, these studies do not offer definitive evidence that Forskolin works as a fat burner. No recommended dosage has been noted. The dosage varies depending on the ailment being treated. Most commonly, the dose forskolin for weight-loss is mg a day. Although forskolin has some reported side effects, it can be considered safe for most healthy adults in all its forms.
Forskolin is a plant and extract used in dietary supplements. Weight management is a journey and we know a complete plan include a healthy diet, exercise and the right supplement. One of the products we like the most is Burn TS. The supplement contains caffeine, green tea, ChromeMate, and Meratrim.
All of the ingredients are backed by research and shown to help boost energy levels, and help curb hunger. Also, the team supporting Burn TS is offering a 2-Week Sample as a sign of confidence in their supplement.
Choosing the right weight-loss system can be confusing and often times frustrating. Let us know a little more about you and your goals. Forskolii, another name for forskolin, some potential side effects include flushing, low blood pressure, restlessness, coughing and throat irritation, according to customers. Forskolin is the chemical found in Plectranthus Barbatus, often referred to as coleus forskholii.
Choosing the right product is the 1 question asked by DietSpotlight readers. We recommend trying any product before buying it and know that finding a product with a sample offer is near impossible - so we created our own product, Burn TS, with scientifically backed ingredients. We did find a couple of studies into the effect of forskolin weight.
One, published more than 10 years age, says it may help with maintenance, but not necessarily loss. Another bit of research shows you need to take the supplement for at least three months for any results at all.
The cost of forskolii depends on the company selling the supplement. You should take forskolin according to the label. Depending on the supplement, you could take it once or twice a day.
Forskolin can be purchased using their Official Site or through Amazon. Traditionally, forskolin has been used to treat heart conditions. In more recent times, the ingredient has been used to fight obesity and erectile dysfunction. Reach out to the customer service team selling the supplement for details.
Forskolin has been used for thousands of years to treat heart conditions, which include chest pain and high blood pressure. It can also be used for respiratory issues like asthma. Forskolin is a chemical that derives from the roots of a plant called Plectranthus Barbatus.
Forskolin is considered to be a weight-loss supplement that gained popularity after it was introduced to the public on the Dr. Oz Show in It derives from the roots of a plant called Indian Coleus. Forskolin extract is derived from Coleus Forskohlii and is an ingredient that is used in different types of natural medicine. Summer Banks, Director of Content at Dietspotlight, has researched over weight-loss programs, pills, shakes and diet plans. Previously, she managed 15 supplement brands, worked with professionals in the weight loss industry and completed coursework in nutrition at Stanford University.
Do Not Send Email Notifications. Nothing works but strict diet. You will loose the fat in a couple of weeks. I used it for i month and gained weight. But they sent me another bottle and said to try again. I had the same type of reaction that kids that are allergic to peanuts have. So it you get puffy and start experiencing a rash or super swelling as I did stop taking immediately.
I have been taking Forskolin for a few days, so no change in weight yet. My main concern is that I called to order 1 free bottle and have ended up with 7! I want to make sure my credit card is not used to order more of this product. So far most of the reviews of this product are very disappointing. Unfortunately there is no official customer service department as many retailers offer this ingredient. You might want to try a supplement that has many positive customer reviews, like Dietspotlight Burn.
I have lose 12 lbs in 3 weeks. I believe this is working for me. I have been taking Forskolin 2x daily for about 30 days. I have lost an incredible amount of weight…22 lbs. I take 1 pill 30 min before breakfast and dinner. I am not hungry between meals and it takes less food to make me full. I have now ordered the mg and am hoping to see even better results.. I give this 2 thumbs up. I too feel misled. If you want to lose weight with a supplement that contains clinically researched ingredients, you may want to try Dietspotlight Burn.
After taking the product for several weeks it appears to be another weight loss product that fails to deliver any results whatsoever. Dr Oz you have misled your followers about this product and i for one will not take any further advice from you. Thanks for telling me the truth. I hate when people back a product that they know does not work just to make money for the company and for them.!!!!!!
Ate a healthy diet,lots of water and these forskolin and rapid cleanse. I lost 2 lbs. Gained this water weight only right back. AND customer service are Fast talkers. I have taken Forskolin for three months 3 bottles and have not lost an ounce. They said money back guarantee. How do I reach them? I purchased Forskolin mg.. The Doctor OZ…It says to take one in morning…I have finish two weeks worth and see weight gain of 2 to three pounds?
However, the orally available forms of AAS may cause liver damage in high doses. Known possible side effects of AAS include: Depending on the length of drug abuse, there is a chance that the immune system can be damaged. Most of these side-effects are dose-dependent, the most common being elevated blood pressure , especially in those with pre-existing hypertension.
AAS have been shown to alter fasting blood sugar and glucose tolerance tests. A number of severe side effects can occur if adolescents use AAS. For example, AAS may prematurely stop the lengthening of bones premature epiphyseal fusion through increased levels of estrogen metabolites , resulting in stunted growth. Other effects include, but are not limited to, accelerated bone maturation , increased frequency and duration of erections, and premature sexual development.
AAS use in adolescence is also correlated with poorer attitudes related to health. Probably carcinogenic to humans. Other side-effects can include alterations in the structure of the heart , such as enlargement and thickening of the left ventricle , which impairs its contraction and relaxation , and therefore reducing ejected blood volume.
AAS use can cause harmful changes in cholesterol levels: AAS use in adolescents quickens bone maturation and may reduce adult height in high doses.
There are also sex-specific side effects of AAS. Development of breast tissue in males, a condition called gynecomastia which is usually caused by high levels of circulating estradiol , may arise because of increased conversion of testosterone to estradiol by the enzyme aromatase. This side-effect is temporary; the size of the testicles usually returns to normal within a few weeks of discontinuing AAS use as normal production of sperm resumes.
Female-specific side effects include increases in body hair , permanent deepening of the voice, enlarged clitoris , and temporary decreases in menstrual cycles. Alteration of fertility and ovarian cysts can also occur in females.
Kidney tests revealed that nine of the ten steroid users developed a condition called focal segmental glomerulosclerosis , a type of scarring within the kidneys. The kidney damage in the bodybuilders has similarities to that seen in morbidly obese patients, but appears to be even more severe. High doses of oral AAS compounds can cause liver damage. A review in CNS Drugs determined that "significant psychiatric symptoms including aggression and violence, mania , and less frequently psychosis and suicide have been associated with steroid abuse.
Long-term steroid abusers may develop symptoms of dependence and withdrawal on discontinuation of AAS". Recreational AAS use appears to be associated with a range of potentially prolonged psychiatric effects, including dependence syndromes, mood disorders , and progression to other forms of substance abuse, but the prevalence and severity of these various effects remains poorly understood. Large-scale long-term studies of psychiatric effects on AAS users are not currently available.
DSM-IV lists General diagnostic criteria for a personality disorder guideline that "The pattern must not be better accounted for as a manifestation of another mental disorder, or to the direct physiological effects of a substance e. As a result, AAS users may get misdiagnosed by a psychiatrist not told about their habit.
Affective disorders have long been recognised as a complication of AAS use. From the mids onward, the media reported "roid rage" as a side effect of AAS. A review determined that some, but not all, randomized controlled studies have found that AAS use correlates with hypomania and increased aggressiveness, but pointed out that attempts to determine whether AAS use triggers violent behavior have failed, primarily because of high rates of non-participation. Compared with individuals that did not use steroids, young adult males that used AAS reported greater involvement in violent behaviors even after controlling for the effects of key demographic variables, previous violent behavior, and polydrug use.
The drug response was highly variable. The mechanism of these variable reactions could not be explained by demographic, psychological, laboratory, or physiological measures.
A study of two pairs of identical twins, in which one twin used AAS and the other did not, found that in both cases the steroid-using twin exhibited high levels of aggressiveness, hostility, anxiety, and paranoid ideation not found in the "control" twin. The relationship between AAS use and depression is inconclusive. There have been anecdotal reports of depression and suicide in teenage steroid users,  but little systematic evidence. A review found that AAS may both relieve and cause depression, and that cessation or diminished use of AAS may also result in depression, but called for additional studies due to disparate data.
Androgens such as testosterone , androstenedione and dihydrotestosterone are required for the development of organs in the male reproductive system , including the seminal vesicles , epididymis , vas deferens , penis and prostate. The pharmacodynamics of AAS are unlike peptide hormones. However, as fat-soluble hormones, AAS are membrane-permeable and influence the nucleus of cells by direct action. The pharmacodynamic action of AAS begin when the exogenous hormone penetrates the membrane of the target cell and binds to an androgen receptor AR located in the cytoplasm of that cell.
From there, the compound hormone-receptor diffuses into the nucleus, where it either alters the expression of genes  or activates processes that send signals to other parts of the cell. The effect of AAS on muscle mass is caused in at least two ways: It has been hypothesized that this reduction in muscle breakdown may occur through AAS inhibiting the action of other steroid hormones called glucocorticoids that promote the breakdown of muscles.
As their name suggests, AAS have two different, but overlapping, types of effects: Some examples of the anabolic effects of these hormones are increased protein synthesis from amino acids , increased appetite, increased bone remodeling and growth, and stimulation of bone marrow , which increases the production of red blood cells.
Through a number of mechanisms AAS stimulate the formation of muscle cells and hence cause an increase in the size of skeletal muscles , leading to increased strength. The androgenic effects of AAS are numerous. Depending on the length of use, the side effects of the steroid can be irreversible. Processes affected include pubertal growth, sebaceous gland oil production, and sexuality especially in fetal development.
Some examples of virilizing effects are growth of the clitoris in females and the penis in male children the adult penis size does not change due to steroids [ medical citation needed ] , increased vocal cord size, increased libido , suppression of natural sex hormones , and impaired production of sperm.
Men may develop an enlargement of breast tissue, known as gynecomastia, testicular atrophy, and a reduced sperm count. Compounds with a high ratio of androgenic to an anabolic effects are the drug of choice in androgen-replacement therapy e. This disassociation is less marked in humans, where all AAS have significant androgenic effects. A commonly used protocol for determining the androgenic: The VP weight is an indicator of the androgenic effect, while the LA weight is an indicator of the anabolic effect.
Two or more batches of rats are castrated and given no treatment and respectively some AAS of interest. Animal studies also found that fat mass was reduced, but most studies in humans failed to elucidate significant fat mass decrements. The effects on lean body mass have been shown to be dose-dependent.
Both muscle hypertrophy and the formation of new muscle fibers have been observed. The hydration of lean mass remains unaffected by AAS use, although small increments of blood volume cannot be ruled out. The upper region of the body thorax, neck, shoulders, and upper arm seems to be more susceptible for AAS than other body regions because of predominance of ARs in the upper body. After drug withdrawal, the effects fade away slowly, but may persist for more than 6—12 weeks after cessation of AAS use.
Overall, the exercise where the most significant improvements were observed is the bench press. The measurement of the dissociation between anabolic and androgenic effects among AAS is based largely on a simple although arguably unsophisticated and outdated model involving rat tissue bioassays. The intracellular metabolism theory explains how and why remarkable dissociation between anabolic and androgenic effects can occur despite the fact that these effects are mediated through the same signaling receptor, and of course why dissociation is invariably incomplete.
An animal study found that two different kinds of androgen response elements could differentially respond to testosterone and DHT upon activation of the AR. Changes in endogenous testosterone levels may also contribute to differences in myotrophic—androgenic ratio between testosterone and synthetic AAS. Testosterone can be metabolized by aromatase into estradiol , and many other AAS can be metabolized into their corresponding estrogenic metabolites as well.
The major effect of estrogenicity is gynecomastia woman-like breasts. AAS are androstane or estrane steroids. As well as others such as 1-dehydrogenation e. The most commonly employed human physiological specimen for detecting AAS usage is urine, although both blood and hair have been investigated for this purpose.
The AAS, whether of endogenous or exogenous origin, are subject to extensive hepatic biotransformation by a variety of enzymatic pathways. The primary urinary metabolites may be detectable for up to 30 days after the last use, depending on the specific agent, dose and route of administration. A number of the drugs have common metabolic pathways, and their excretion profiles may overlap those of the endogenous steroids, making interpretation of testing results a very significant challenge to the analytical chemist.
Methods for detection of the substances or their excretion products in urine specimens usually involve gas chromatography—mass spectrometry or liquid chromatography-mass spectrometry. The use of gonadal steroids pre-dates their identification and isolation. Medical use of testicle extract began in the late 19th century while its effects on strength were still being studied. In the s, it was already known that the testes contain a more powerful androgen than androstenone , and three groups of scientists, funded by competing pharmaceutical companies in the Netherlands, Germany, and Switzerland, raced to isolate it.
The chemical synthesis of testosterone was achieved in August that year, when Butenandt and G. Wettstein, announced a patent application in a paper "On the Artificial Preparation of the Testicular Hormone Testosterone Androstenoneol. Clinical trials on humans, involving either oral doses of methyltestosterone or injections of testosterone propionate , began as early as Kennedy was administered steroids both before and during his presidency.
The development of muscle-building properties of testosterone was pursued in the s, in the Soviet Union and in Eastern Bloc countries such as East Germany, where steroid programs were used to enhance the performance of Olympic and other amateur weight lifters. In response to the success of Russian weightlifters, the U. The new steroid was approved for use in the U.
It was most commonly administered to burn victims and the elderly. The drug's off-label users were mostly bodybuilders and weight lifters. Although Ziegler prescribed only small doses to athletes, he soon discovered that those having abused Dianabol suffered from enlarged prostates and atrophied testes. Three major ideas governed modifications of testosterone into a multitude of AAS: Androgens were discovered in the s and were characterized as having effects described as androgenic i.
Although anabolic steroid was originally intended to specifically describe testosterone-derived steroids with a marked dissociation of anabolic and androgenic effect, it is applied today indiscriminately to all steroids with AR agonism-based anabolic effects regardless of their androgenic potency, including even non-synthetic steroids like testosterone itself. The legal status of AAS varies from country to country: Unlawful distribution or possession with intent to distribute AAS as a first offense is punished by up to ten years in prison.
Those guilty of buying or selling AAS in Canada can be imprisoned for up to 18 months. In Canada, researchers have concluded that steroid use among student athletes is extremely widespread. A study conducted in by the Canadian Centre for Drug-Free Sport found that nearly 83, Canadians between the ages of 11 and 18 use steroids.
AAS are readily available without a prescription in some countries such as Mexico and Thailand. The history of the U. The same act also introduced more stringent controls with higher criminal penalties for offenses involving the illegal distribution of AAS and human growth hormone.
By the early s, after AAS were scheduled in the U. In the Controlled Substances Act, AAS are defined to be any drug or hormonal substance chemically and pharmacologically related to testosterone other than estrogens , progestins , and corticosteroids that promote muscle growth. The act was amended by the Anabolic Steroid Control Act of , which added prohormones to the list of controlled substances , with effect from January 20, In the United Kingdom, AAS are classified as class C drugs for their illegal abuse potential, which puts them in the same class as benzodiazepines.
Part 1 drugs are subject to full import and export controls with possession being an offence without an appropriate prescription. There is no restriction on the possession when it is part of a medicinal product. Part 2 drugs require a Home Office licence for importation and export unless the substance is in the form of a medicinal product and is for self-administration by a person. Many other countries have similar legislation prohibiting AAS in sports including Denmark,  France,  the Netherlands  and Sweden.
United States federal law enforcement officials have expressed concern about AAS use by police officers. It's not that we set out to target cops, but when we're in the middle of an active investigation into steroids, there have been quite a few cases that have led back to police officers," says Lawrence Payne, a spokesman for the United States Drug Enforcement Administration. Following the murder-suicide of Chris Benoit in , the Oversight and Government Reform Committee investigated steroid usage in the wrestling industry.
The documents stated that 75 wrestlers—roughly 40 percent—had tested positive for drug use since , most commonly for steroids. AAS are frequently produced in pharmaceutical laboratories, but, in nations where stricter laws are present, they are also produced in small home-made underground laboratories, usually from raw substances imported from abroad.
As with most significant smuggling operations, organized crime is involved. In the late s, the worldwide trade in illicit AAS increased significantly, and authorities announced record captures on three continents. In , Finnish authorities announced a record seizure of A year later, the DEA seized In the first three months of , Australian customs reported a record seizures of AAS shipments. Illegal AAS are sometimes sold at gyms and competitions, and through the mail, but may also be obtained through pharmacists, veterinarians, and physicians.
AAS, alone and in combination with progestogens , have been studied as potential male hormonal contraceptives. From Wikipedia, the free encyclopedia. This article is about androgens as medications. For androgens as natural hormones, see Androgen.
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