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Be sure to talk to your doctor and get blood work done before starting. There's a great app for iOs and Android called Fat Secret not affiliated terrible name, but great app. Most computers come with this installed. So, how long does Nutrisystem take to work? The hardest thing for me to give up when I started Nutrisystem was bacon. I still use Nutrisystem's "Numi" app, I'm still following the program, and I'm still losing weight.
There are a few that appear to be mildly effective. This includes Caffeine, Green Tea and Glucomannan (a fiber that can reduce appetite). However, the results are usually weak and inconsistent and certainly nothing to get excited about.
At the end of the day, the only thing that is really proven to help you lose weight is changing your diet.